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“Murder, She Wrote” started on CBS in 1984, starring Angela Lansbury as mystery writer and amateur detective Jessica Fletcher.  The show ran for 12 seasons and 264 episodes, becoming one of the most successful TV shows in history.  The series was syndicated around the world.  Episodes are available for streaming on Netflix.

“Murder, She Wrote” also led to four TV movies, two video games and a short-lived spinoff in 1987 (”The Law & Harry McGraw”). 

Source: Wikipedia (Murder, She Wrote)