The absolute king of the surprising guest star series would have to be Gunsmoke, a Western that was only recently overtaken as the longest-running drama series on television.
You turn it on, and you might see…hey, Leonard Nimoy as an Indian:
“This series presents information based in part on theory and conjecture. The producer’s purpose is to suggest some possible explanations, but not necessarily the only ones, to the mysteries we will examine.“
So went the disclaimer before Leonard Nimoy went "In Search Of…” Amelia Earhart or Bigfoot or The Loch Ness Monster back in 1977-82.